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Since the Animal Core will be generating and delivering mice to all three projects, the core will be a source for the characterization of the different mutant mice generated in each of the projects and will characterize and provide expression of the protein of interest at the protein level by Western Blot, Immunohistochemistry, and Immunocytochemistry. To provide a unified animal model, the Animal Core will generate all three mutant mouse models (knock-in, knock-out, and transgenic) required for all projects in the Center (Projects 1, 2, and 3). The Core will be comprised of three major sections: 1) Mice Production, 2) Animal Maintenance, and 3) Mouse Characterization. Mice Production will be responsible for creating the mice, breeding the mice, maintaining the colony, and shipping the mice to the projects as required. Mice Maintenance will maintain and breed the mice and ship mice to projects as required. 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